Code and Data

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All scripts utilize the package microtubule-meganwang08 which you can find here

Code

• EDA_fluorescent_labeling.py | Exploratory data analysis first visualizing the labeled vs unlabled microtubule subunits in catastrope.

• poisson_modeling_microtubule.py | Models microtubule catastrope as a poisson process.

• confint_microtubule.py | Graphs confience intervals for the EDA of fluorescent labeling.

• MLE_of_microtubules.py | MLE of microtubule catastrophe data modeled with both gamma and poisson distributions.

• model_comparison_microtubule.py | Comparing gamma and poisson distributions from MLE_of_microtubules.

• dashboard.py | Interactive dashboard of our proposed model for microtubule time to catastrophe.

Data Sets

• Microtubule time to catastrophe | (filetype: .csv)(5 kb)

• Microtubule time to catastrophe only tubulin | (filetype: .csv)(11 kb)

Figure Generation

Fig. 1: ECDF of Onset of Labeled and Unlabled Tubulin Catastrophe

Used to generate Figure 1.

Necessary Data Sets
- Microtubule time to catastrophe

Fig. 2: Simulating Microtubule Catastrophe as a Multivariate Normal Process.

Used to generate Figure 2.

Necessary Data Sets
- Microtubule time to catastrophe

Fig. 3: Wait times for Microtubule Catastrophe

Used to generate Figure 3.

Necessary Data Sets
- Microtubule time to catastrophe

Fig. 4: Wait times for Microtubule Catastrophe

Used to generate Figure 4.

Necessary Data Sets
- Microtubule time to catastrophe only tubulin

Fig. 5: Comparing Poisson and Gamma Microtubule Distributions

Used to generate Figure 5.

Necessary Data Sets
- Microtubule time to catastrophe only tubulin